A compartmental CFD-PBM model of high shear wet granulation

A Multi-Scale Hybrid CFD-DEM-PBM Description of a Fluid-Bed Granulation Process

In this study, a hybrid multi-scale model has been developed for a continuous fluid bed wet granulation process by dynamically coupling computational fluid dynamics (CFD) with a discrete element model (DEM) and population balance model (PBM). In this process, the granules are formed by spraying the liquid binder on the fluidized powder bed. The fluid flow field has been solved implementing CFD ...

A multi-compartment population balance model for high shear granulation

This work extends the granulation model published by Braumann et al. (2007) (Chemical Engineering Science, 62, 4717-4728) to include multiple compartments in order to account for mixture heterogeneity encountered in powder mixing processes. A stochastic weighted algorithm is adapted to solve the granulation model which includes simultaneous coalescence and breakage. Then, a new numerical method...

Scale-up studies on high shear wet granulation process from mini-scale to commercial scale.

A newly developed mini-scale high shear granulator was used for scale-up study of wet granulation process from 0.2 to 200 L scales. Under various operation conditions and granulation bowl sizes, powder mixture composed of anhydrous caffeine, D-mannitol, dibasic calcium phosphate, pregelatinized starch and corn starch was granulated by adding water. The granules were tabletted, and disintegratio...

A PAT approach to improve process understanding of high shear wet granulation through in-line particle measurement using FBRM C35.

This article summarizes the investigation of in-line particle characterization during high shear wet granulation (HSWG) using focused beam reflectance measurement (FBRM) for enhanced process understanding, which is part of an effort to develop this drug product within the framework of quality by design (QbD) and process analytical technology (PAT). Traditionally, the effectiveness of in-line mo...

Effect of operating conditions and physico–chemical properties on the wet granulation kinetics in high shear mixer